Dataset # |
Left Side |
a,b,c,d |
Compared with |
Result |
|
|
|
|
|
1 |
Disease |
20,6,0,5 |
ExactBB |
Exact limits and p-values OK |
2 |
Disease |
2,2,4,6 6,4,2,0 3,0,1,1 8,4,1,1 19,10,8,8 |
Martin, |
CMLE odds ratio, Fisher and mid P results agree. MH chi is 0.374 vs. |
3 |
Exposure |
27,95,44,443 |
SAS proc FREQ |
Agreement |
4 |
Exposure |
23,74,20,134 4,21,24,309 |
SAS |
Agreement except that method of calculating 2-sided confidence limits from 1-sided seems to be different. |
5 |
Exposure |
451,39,1729,636 |
ATFRAC |
Agreement for OR based etiologic fraction and CLs. |
6 |
Disease |
451,1729,39,636 |
Stat22 |
Agreement, but OpenEpi unable to calculate Fisher and midP |
7 |
Disease |
Same as 6 |
ExactMA |
Same result as 6 |
8 |
Disease |
39,451,636,1729 |
ExactMA |
Calculations agree and OpenEpi can compute, but p values “mostly zeroes”. |
9 |
Disease |
Same as 6 |
Stats Direct |
Same as 6 |
10 |
Disease |
Same as 8 |
Stats Direct |
Same as 8. Prevented fraction not available from Stats Direct. |
11 |
Disease |
72,20,684,553 |
Walter, IJE 1978;7;2. Table 2 |
Good agreement |
12 |
Disease |
4,386,4,1250 |
Rothman, EpiSheet, Downloaded Nov 2003 |
Good agreement. 2-sided confidence intervals calculated the same way as OpenEpi (doubling the minimum of the one-sided exact), and agree. |
13 |
Disease |
3,9,104,1059 1,3,5,86 |
Rothman, EpiSheet, Downloaded Nov 2003 |
Rothman values labeled RR and mhRR are actually odds ratios, and agree with OpenEpi odds ratios. |
14 |
Disease |
8,5,98,115 22,16,76,69 |
Rothman, EpiSheet, Downloaded Nov 2003 |
ok |
15 |
Disease |
32,2,52407,18790 104,12,43248,10673 206,28,28612,5710 186,28,12663,2585 102,31,5317,1462 |
Rothman, EpiSheet, Downloaded Nov 2003 |
Rothman’s RR and mhRR are really odds ratios. RDs and other parameters agree. |
16 |
Exposure |
27,95,44,443 |
Epi Info 2002, Ver 2 |
Good agreement |
17 |
Exposure |
1,2,3,4 |
Epi Info, Ver 3 |
Good agreement |
18 |
Exposure |
22,6,3,16 20,5,0,2 |
Epi Info, Ver 3 |
Good agreement |
19 |
Exposure |
43,11,3,18 |
Epi Info, Ver 3 |
Good agreement |
20 |
Exposure |
27,4,3,10 16,7,0,8 |
Epi Info, Ver 3 |
Good agreement |
21 |
Exposure |
1,0,2,3 |
Epi Info, Ver 3 |
Agreement. |
22 |
Exposure |
66,28,36,32 139,61,93,54 |
Sullivan, Unpublished chapter, with hand-calculated results, downloadable with OpenEpi. Click HELP in TwobyTwo. |
Agreement. |
By Andy Dean with a great deal of help from
Conclusions: There are some issues to resolve about terminology for upper and lower one-sided exact confidence limits, and concerning whether to add 0.5 to each cell if a cell is 0, but otherwise TwoByTwo seems ready to release for serious use, although it is always a good idea to check important conclusions with more than one program.